Serum Procollagen Type I N-Terminal Propeptide (PINP) in Adults with Type 2 Diabetes Mellitus in Kalar, Kurdistan Region of Iraq

Abstract

Background: Type 2 diabetes mellitus  (T2DM) is known to be associated with an increased susceptibility of fractures despite normal or high bone mineral density, indicating the poor quality of bones and abnormal collagen turnover. Procollagen type I N-terminal propeptide (PINP) is a sensitive biochemical marker of bone formation and collagenogenesis. Objectives: To evaluate serum PINP concentrations and some metabolic parameters in patients with T2DM compared to healthy controls. Materials and Methods: This cross-sectional study comprised 42 T2DM and 37 healthy participants between the age of 40 and 70 years. Fasting Blood Samples for measuring fasting plasma glucose (c), A1C, Triglycerides, Total Cholesterol, Albumin Bound-Calcium (AB-Ca), ALP and PINP were drawn after an overnight fast. Biochemical indexes were detected by automated analyzer, and PINP was detected by enzyme linked immunosorbent assay. Statistical analyses unpaired t tests and Chi-square tests were used for statistical comparisons. Results: FPG, A1C, and triglyceride were higher in T2DM participants as compared to controls (P = 0.001, P = 0.001, and P = 0.032 respectively). Both hypertension and sedentary life style were more frequent in diabetic subjects (P = 0.032 and P = 0.016). There were no significant differences in total cholesterol, albumin, calcium level and ALP, or serum concentrations between the two groups (460.7 ± 139.2 pg/mL vs 412.5 ± 127.7 pg/mL; P = 0.208). Conclusion: Serum PINP, calcium, and ALP shown no significant variation in patients with type 2 diabetes mellitus.